Murine double minute 2 309 T>G polymorphism is associated with gastrointestinal cancer risk especially in Asians: a meta-analysis

Objective To comprehensively evaluate the relationship between murine double minute 2(MDM2) gene promoter SNP309 T>G polymorphism and the susceptibility of gastrointestinal cancer. Methods The China National Knowledge Infrastructure (CNKI), WanFang database, SpringerLink database and PubMed were retrieved to get all case-control research literatures (2005-2012) on the relationship of MDM2 gene SNP309 T>G and gastrointestinal cancer susceptibility. Meta-analysis with RevMan 4.2 was used to combine OR values of the relationship between SNP309 T>G and gastrointestinal cancer susceptibility. A sensitivity analysis and tested publication bias were made with all selected literatures' data. Results A total of 17 domestic and foreign qualified papers were included in this study. Twenty case-control studies including 5 183 cases and 6 660 controls were identified for the present meta-analysis. A significant association was detected between the MDM2 SNP309 T>G polymorphism and gastrointestinal cancer risk. The meta-analysis showed that the combined odds ratio (OR) for GG genotype was 2.23 (95 % CI=1.73-2.89, P<0.01) compared with that for TG + TT genotypes. There was no statistical significance for the evaluation of publication bias. Conclusion The GG genotype of MDM2 SNP309 may increase gastrointestinal cancer risk in Asians. Key words: Murine double minute 2; SNP309 T>G; Gastrointestinal cancer; Meta-analysis