Recent progress in structural studies on canonical TRP ion channels

Canonical TRP channels (TRPC) are non-selective cation channels that are involved in various important physiological processes. Currently, the structures of different TRPC ion channel family members are resolved by cryo-EM at resolutions ranging from 2.8 Å to 5.8 Å. These structures reveal the conserved architecture of TRPC ion channels as well as the specific features of each channel subtype. This review focuses on the structural differences in the extracellular portions, transmembrane domains and the cytoplasmic domains of TRPC channels.