How organoids from endometrium and endometriosis could help to understand the pathogenesis of endometriosis

The article on methylation of HOX genes (1) in endometrium and endometriosis organoids is carefully performed and important research. Organoids, or the in vitro culture of cells as three-dimensional structures, are a rapidly developing new technology. The most important advantage of organoids is their phenotypic and genetic stability and long-lasting commitment to the tissue of origin during long-term culture (2). This characteristic was previously found only in specific immortalized monolayer cultured cell lines, which unfortunately differed from the original cells in many aspects.