[Resistance of Acinetobacter baumannii to Tigecycline].

OBJECTIVES: . METHODS: (b38!d) were cultured separately and conjointly to evaluate its fitness costs of tigecycline resistance. RESULTS: Tigecycline resistant strains were successfully induced using multi-step method. Ultraviolet radiation did not change the sensitivity of the three strains to tigecycline, but elevated the MICs of tigecycline. The MICs of tigecycline did not change over 40 generations. It took much more time for the resistant strains to reach logarithmic growth phase and plateau phase compared with the tigecycline sensitive strains. With repeated passage, the tigecycline resistant strains decreased rapidly, even vanished in conjointly culture. CONCLUSION: can acquire tigecycline resistance. The resistance may have genetic stability. The resistant strains have less adaptability than the sensitive strains.