α-Glucosidase and non-enzymatic glycation inhibitory potential of Eugenia dysenterica fruit pulp extracts

Abstract Considering the nutritional benefits of fruits on human health, this study aimed to screen 11 fruits found in the Brazilian Savanna for glycoside hydrolases inhibitors with antioxidant and anti-glycation properties. Aqueous and ethanol extracts of pulps were used in enzymatic assays to evaluate the inhibitory potential against α-amylase and α-glucosidase, as well as antioxidant (2,2-diphenyl-1-picrylhydrazyl (DPPH) and oxygen radical absorbance capacity (ORAC) assays) and anti-glycation (BSA-fructose model) capacities. Ethanol extracts of Campomanesia xanthocarpa, Byrsonima verbascifolia and Eugenia dysenterica had the lowest DPPH IC50 values ( 0.60 mmol trolox equivalents/g). The extracts of E. dysenterica showed potential to inhibit glycation (IC50