转录因子
HEK 293细胞
生物
基因
Sp3转录因子
基因表达
抄写(语言学)
一般转录因子
TCF4型
细胞生物学
分子生物学
发起人
遗传学
增强子
语言学
哲学
作者
Oleh V. Halkin,О. H. Minchenko
摘要
The transcription factor ZXDC, a member of ZXD protein family, forms transcriptionally active complex with ZXDA and participates in the regulation of MHCII gene expression. In this work we investigate the expression of a large group of genes in kidney embry cell of line HEK293 with overexpression of transcription factor ZXDC for identification of genes, which transcription is controlled by this transcription factor. We have shown that overexpression of the transcription factor ZXDC in kidney embryo cell of HEK293 line significantly changes the level of expression of large group of genes, which control the behavior of different cell processes, in particular cell cycle, cell proliferation and differentiation. The expression of most of these genes is significantly increased in the kidney cell line HEK293 with overexpression of transcription factor ZXDC, in particular EGR2, BDNF, CDKN1C and IL5Ra genes. Our results clearly demonstrated that transcription factor ZXDC plays a significant role in the regulation of expression of a large group of genes, which control important cell processes.
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