Deep eutectic solvents: Recent advances in fabrication approaches and pharmaceutical applications

Deep eutectic solvents (DESs) have received increasing attention in the past decade owing to their distinguished properties including biocompatibility, tunability, thermal and chemical stability. Particularly, DESs have joined forces in pharmaceutical industry, not only to efficiently separate actives from natural products, but also to dramatically increase solubility and permeability of drugs, both are critical for the drug absorption and efficacy. As a result, lately DESs have been extensively and practically adopted as versatile drug delivery systems for different routes such as nasal, transdermal and oral administration with enhanced bioavailability. This review summarizes the emerging progress of DESs by introducing applied fabrication approaches with advantages and limitations thereof, and by highlighting the pharmaceutical applications of DESs.