胎儿游离DNA
鉴定(生物学)
生物标志物
计算生物学
液体活检
生物信息学
肺癌
疾病
医学
分子诊断学
癌症
肿瘤科
内科学
生物
遗传学
胎儿
产前诊断
怀孕
植物
生物化学
作者
Yu Chen,Yuxin Gong,Lijun Dou,Xinlan Zhou,Yan Zhang
标识
DOI:10.1016/j.compbiomed.2022.105283
摘要
As a kind of novel non-invasive marker for molecular detection, cell-free DNA (cfDNA) has potential value for the early diagnosis of diseases, prognosis assessment, and efficacy monitoring. The constant developments in molecular biology detection technologies have led to an increase in clinical studies on the use of cfDNA detection methods for patients, and many gratifying outcomes have been achieved. In this review, the contributions of bioinformatics tools to the study of cfDNA are well discussed. The focus of the review is on cfDNA identification signals, cfDNA identification methods, and the relationship of cfDNA with human diseases such as hepatic cancer, lung cancer, end-stage kidney disease, and ischemic stroke. The research significance and existing problems of using cfDNA as a biomarker for diseases are also discussed.
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