Objective To investigate the effect of pars plana capsulotomy and vitrectomy with infusion through the limbus to remove the posterior capsule opacification (PCO).Methods The data of 27 eyes of 23 patients with PCO, who were undergone pars plana capsulotomy and vitrectomy with infusion through the limbus, were respectively analysed.All the patients were followed-up for 6~18 months.Results The central opaque posterior capsule and anterior vitreous were successfully removed in all patients without complication.A round hole with 3.0~6.0 mm diameter was obtained at the posterior capsule.The visual acuity in all patients was improved; There were no complication during the postoperative follow-up period, such as dislocation or damage of the IOL, retina detachment and PCO again.Conclusion Pars plana capsulotomy and vitrectomy with infusion through the limbus is a safe and effective to remove the PCO.