Preparation and quality control of compound levofloxacin gel

Aim To prepare compound levofloxacin gel and establish quality control methods.Methods Using carbopol-940 as the base material and levofloxacin,tinidazole as main ingredients,compound levofloxacin gel was prepared.The UV spectrophotometry was adopted for detemination of levofloxacin and tinidazole.Results The compound levofloxacin gel was coherent and stable.The calibration curve of levofloxacin and tinidazole were linear in the ranges of 3.0～8.0μg·ml -1 and 12.0～32.0μg·ml -1,respectively.The arverage recovery rates of levofloxacin and tinidazole were 100.15% and 100.14%,their RSD is 0.84% and 1.31%,respectively.Conclusion The preparation was simple,the method of content determination was simple and accurate.