This paper introduces the Gaia theory in brief. The theory claims that the biosphere and the non-living matters could be regarded as a self-regulating system. Scientists on Gaia think that biology not only adapts to physical environment, but regulates the global condition actively. The correlation between Gaia theory and the study of earth system science is analyzed in this paper, too. We suggest that ① the theory plays an important role in studying global change, geological events and biology evolution, ② the panorama of the earth evolution can be understood more clearly on the basis of Gaia, ③ recognizing the regulation of biosphere is necessary for estimating the global change and interaction between the geospheres.