The development of locus coeruleus neurons in human fetus

Objective To explore the development of locus coeruleus neurons in human fetus and supply morphological basis to selecting fitter embryoml of locus coeruleus cells in fetal locus coeruleus transplanted into transected spinal cord.Method The development of locus coeruleus neurons in 4￣ 8 monthes human fetus with the Nissl staining in this experiment was observed sys tematically.Result The locus coeruleus neurons had beenfound at the fourth month embryon.The numberof locus coeruleus neurons decreased graduallywith fetal ages. The body of locus coeruleusneurons was getting small to big. The locuscoeruleus neuron was round, oval, Pyra￣l,spindle and angular in shape. The density ofneurons increased in early embryon and decreasesgradully with fetal ages in late embryonic. The neurons are mainly located in dorsal of locuscoeruleus.Conclusion The neurons of locus coeruleus inhuman embryon of the foutth month seems tO befitter for graft.