Expression of p16 and nm23 and the clinical significance in laryngeal carcinoma

Objective:To study the expression of p16 and nm23 and the clinical significance in laryngeal carcinoma.Methods: p16 and nm23 protein expressions in 53 cases of laryngeal carcinoma were detected by immunohistochemistry(SP method),with normal laryngeal epithelium as control.Results:In laryngeal carcinoma,the positive rates of p16 and nm23 were 47.2%(25/53) and 52.8%(28/53),respectively.The p16 positive rate in grade Ⅱ and Ⅲ carcinoma was lower than that in grade Ⅰ carcinoma(P0.01),in neck lymph nodes with metastasis was lower than in neck lymph nodes without metastasis(P0.05).The nm23 positive rate in PTNM Ⅰ and Ⅱ carcinoma was higher than that in PTNM Ⅲ and Ⅳ carcinoma (P0.01),in neck lymph nodes with metastasis was lower than in neck lymph nodes without metastasis(P0.01).Conclusion:The expression of p16 protein might be related to the degree of differentiation and cervical lymph node metastasis,the expression of nm23 might be related to the clinical staging and cervical lymph node metastasis.Detection of the above parameters could have significance in predicting the biological aggressiveness and clinical outcome of laryngeal carcinoma,which may guide to make the therapeutic decision.