Due to the optical and electrical properties of nanostructure,HgTe are much easier adjusted than ot-her Ⅱ-Ⅵ semiconductor materials,HgTe quantum as fluorescence probe have the potential to be used in imaging of biology cell and tissue.The structure and properies of HgTe are introduced briefly and the preparation of nanostructure HgTe via physical and chemical methods in domestic and foreign are reviewed.The application prospect of nanostructure HgTe is also concluded.