体内
分散性
小分子
肽
生物活性
药物发现
聚合物
球状蛋白
化学
融合蛋白
计算生物学
生物化学
体外
组合化学
生物
重组DNA
生物技术
有机化学
基因
作者
Vladimir N. Podust,Sibu Balan,Bee-Cheng Sim,Michael P. Coyle,Ulrich Ernst,Robert Peters,Volker Schellenberger
标识
DOI:10.1016/j.jconrel.2015.10.038
摘要
XTEN™ is a class of unstructured hydrophilic, biodegradable protein polymers designed to increase the half-lives of therapeutic peptides and proteins. XTEN polymers and XTEN fusion proteins are typically expressed in Escherichia coli and purified by conventional protein chromatography as monodisperse polypeptides of exact length and sequence. Unstructured XTEN polypeptides have hydrodynamic volumes significantly larger than typical globular proteins of similar mass, thus imparting a bulking effect to the therapeutic payloads attached to them. Since their invention, XTEN polypeptides have been utilized to extend the half-lives of a variety of peptide- and protein-based therapeutics. Multiple clinical and preclinical studies and related drug discovery and development efforts are in progress. This review details the most current understanding of physicochemical properties and biological behavior of XTEN and XTENylated molecules. Additionally, the development path and status of several advanced drug discovery and development efforts are highlighted.
科研通智能强力驱动
Strongly Powered by AbleSci AI