Perindopril 3.5 mg/amlodipine 2.5 mg versus renin–angiotensin system inhibitor monotherapy as first-line treatment in hypertension

In a large patient population, early administration of P3.5/A2.5 resulted in a significantly greater BP-lowering effect than perindopril, irbesartan or valsartan monotherapies after 1 month. Reducing BP levels within a month of treatment may reasonably be expected to lead to a reduced risk of cardiovascular events.