Effects of Several Auxiliary Materials on the Particle Size and Zeta Potential of Paclitaxel Liposome

[Objective] To identify the effects of several auxiliary materials on the particle size and Zeta potential of Tax liposome. [Method] Tax liposome was prepared with film dispersed-ultrasonic method, the orthogonal test was adopted to select the optimal formulation of Tax liposome, and to detect the particle size and Zeta potential of Tax liposome. [Result] The particle size and stability of liposome were significantly influenced by the materials such as eunatrol. And with the increasing amount of those materials, the particle size of liposome became small, Zeta potential value decreased, while the stability improved. [Conclusion] Materials like eunatrol could significantly decrease the particle size and Zeta potential of Tax liposome, the Tax liposome prepared with the optimal technology had high entrapment efficiency, even particle size and good stability.