The Cover Feature shows the bionic calcification-based strategy in cancer diagnosis and therapy. Molecules with the calcium-ion-recruiting property could target tumor cells specifically after systemic administration. This favors the growth of calcium minerals around cancer cells, subsequently inducing the stagnation of tumor tissue proliferation and realizing the clinical treatment of tumors. Meanwhile, the strategy of tumor calcification could be applied to early-stage diagnosis with the assistance of medical imaging techniques such as ultrasound, computed tomography, etc.. More information can be found in the Concept by Ben Wang et al.