Bio-molecular interactions: blood components, cells and biomaterials in the regeneration of acellular vascular grafts

Cardiovascular disease is the leading cause of death worldwide, the requirement of vascular grafts, intended to replace the function of a blood vessel remains of main importance. Available vascular grafts in the market are not successful in some conditions. One of the failure causes for synthetic vascular grafts is the patency loss that occurs as a result of an alteration of the physiological behavior of the cells and blood components in the vascular tissue when in operation conditions. Even when the tissue engineering and regenerative medicine fields have proposed strategies to overcome these limitations, the design of regenerative vascular grafts is challenging given that they must promote and properly guide tissue regeneration. In consequence, this works aims for the analysis and evaluation of the bio-molecular interactions between the blood components, cells and biomaterials that have been reported during the regeneration of vascular useful for rational design of vascular grafts.