河马信号通路
肿瘤微环境
三阴性乳腺癌
癌症研究
间质细胞
免疫系统
转移
癌变
乳腺癌
肿瘤进展
生物
癌症
信号转导
免疫学
医学
细胞生物学
内科学
作者
Zheng Wang,Fan Wang,Xinyuan Ding,Tian-En Li,Haoyu Wang,Yuhao Gao,Wen‐Juan Wang,Yanfeng Liu,Xiao-Song Chen,Kunwei Shen
标识
DOI:10.1016/j.canlet.2021.12.016
摘要
Growing evidence suggests that the bidirectional interactions between cancer cells and their surrounding environment, namely the tumor microenvironment (TME), contribute to cancer progression, metastasis, and resistance to treatment. Intense investigation of the Hippo pathway, which controls multiple central cellular functions in tumorigenesis, was focused on cancer cells. However, the role of the Hippo pathway in modulating tumor-stromal interactions in triple-negative breast cancer remains largely unknown. Therefore, this study focused on revealing the effects of Hippo-YAP/TAZ signaling on the immune microenvironment. Our findings reveal that the activity of the Hippo pathway is associated with worse disease outcomes in TNBC and could increase TAM infiltration through the TAZ/IL-34 axis, leading to an immunosuppressive microenvironment and impairing the treatment efficacy of anti-PD-L1. Thus, the TAZ/IL-34 axis may serve as a novel target for TNBC patients.
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