RNA结合蛋白
核糖核酸
癌症
癌症免疫疗法
计算生物学
生物
癌症研究
免疫疗法
医学
基因
生物化学
遗传学
作者
Rama Kashikar,Arun K. Kotha,Saurabh Shah,Paras Famta,Shashi Bala Singh,Saurabh Srivastava,Mahavir B. Chougule
标识
DOI:10.1016/j.addr.2022.114257
摘要
RNA binding proteins (RBPs) enact a very crucial part in the RNA directive processes. Atypical expression of these RBPs affects many steps of RNA metabolism, majorly altering its expression. Altered expression and dysfunction of RNA binding proteins lead to cancer progression and other diseases. We enumerate various available interventions, and recent findings focused on targeting RBPs for cancer therapy and diagnosis. The treatment, sensitization, chemoprevention, gene-mediated, and virus mediated interventions were studied to treat and diagnose cancer. The application of passively and actively targeted lipidic nanoparticles, polymeric nanoparticles, virus-based particles, and vaccine-based immunotherapy for the delivery of therapeutic agent/s against cancer are discussed. We also discuss the formulation aspect of nanoparticles for achieving delivery at the site of action and ongoing clinical trials targeting RBPs.
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