核糖核酸
计算生物学
生物
功能(生物学)
招股说明书
生物信息学
基因
细胞生物学
遗传学
财务
经济
作者
Yiran Zhu,Liyuan Zhu,Xian Wang,Hongchuan Jin
标识
DOI:10.1038/s41419-022-05075-2
摘要
Abstract The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto “undruggable” proteins, transcripts and genes, thus potentially broadening the therapeutic targets. Several RNA-based medications have been approved for clinical use, while others are still under investigation or preclinical trials. Various techniques have been explored to promote RNA intracellular trafficking and metabolic stability, despite significant challenges in developing RNA-based therapeutics. In this review, the mechanisms of action, challenges, solutions, and clinical application of RNA-based therapeutics have been comprehensively summarized.
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