寄主(生物学)
免疫学
移植物抗宿主病
CD8型
干细胞
生物
免疫系统
细胞生物学
遗传学
作者
Yi Zhang,Gerard Joe,Elizabeth O. Hexner,Jiang Zhu,Stephen G. Emerson
出处
期刊:Nature Medicine
[Springer Nature]
日期:2005-11-20
卷期号:11 (12): 1299-1305
被引量:328
摘要
Graft-versus-host disease (GVHD) is caused by alloreactive donor T cells that trigger host tissue injury. GVHD develops over weeks or months, but how this immune response is maintained over time is unknown. In mouse models of human GVHD, we identify a new subset of postmitotic CD44loCD62LhiCD8+ T cells that generate and sustain all allogeneic T-cell subsets in GVHD reactions, including central memory, effector memory and effector CD8+ T cells, while self-renewing. These cells express Sca-1, CD122 and Bcl-2, and induce GVHD upon transfer into secondary recipients. The postmitotic CD44loCD62LhiCD8+ T cells persist throughout the course of GVHD, are generated in the initial phase in response to alloantigens and dendritic cells and require interleukin-15. Thus, their long life, ability to self-renew and multipotentiality define these cells as candidate memory stem cells. Memory stem cells will be important targets for understanding and influencing diverse chronic immune reactions, including GVHD.
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