MPTP公司
协议(科学)
计算机科学
神经毒素
帕金森病
医学
神经科学
疾病
生物
病理
替代医学
内科学
作者
Vernice Jackson‐Lewis,Serge Przedborski
出处
期刊:Nature Protocols
[Springer Nature]
日期:2007-01-01
卷期号:2 (1): 141-151
被引量:830
标识
DOI:10.1038/nprot.2006.342
摘要
This protocol describes our method of producing a reliable mouse model of Parkinson's disease (PD) using the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). We discuss the particulars of the model, provide key references and outline what investigators need to know to develop the MPTP mouse model of PD safely and successfully. Completion of this protocol depends on the regimen of MPTP used and on the actual planned studies, which often range from 7 to 30 d. This protocol calls for implementation of safety measures and for the acquisition of several pieces of equipment, which are a one-time investment worth making if one elects to use this model on a regular basis.
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