Darbepoetin decreased transfusions and fatigue, but increased adverse effects in patients with chronic kidney disease, diabetes, and anemia

ACP Journal Club16 March 2010Darbepoetin decreased transfusions and fatigue, but increased adverse effects in patients with chronic kidney disease, diabetes, and anemiaTejas V. Patel, MD, MPH, FACP, FASNTejas V. Patel, MD, MPH, FACP, FASNBrigham and Women’s Hospital, Boston, Massachusetts, USA (T.V.P.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-152-6-201003160-02009 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationPfeffer MA, Burdmann EA, Chen CY, et al. A trial of darbepoetin alfa in type 2 diabetes and chronic kidney disease. N Engl J Med. 2009;361:2019−32. https://pubmed.ncbi.nlm.nih.gov/19880844Clinical Impact RatingsEndocrinology: Hematology: Nephrology: References1 Canadian Erythropoietin Study Group. Association between recombinant human erythropoietin and quality of life and exercise capacity of patients receiving haemodialysis. BMJ. 1990;300:573-8. [PMID: 2108751] Google Scholar2 Besarab A, Bolton WK, Browne JK, et al. The effects of normal as compared with low hematocrit values in patients with cardiac disease who are receiving hemodialysis and epoetin. N Engl J Med. 1998;339:584-90. [PMID: 9718377] Google Scholar3 Singh AK, Szczech L, Tang KL, et al. Correction of anemia with epoetin alfa in chronic kidney disease. N Engl J Med. 2006;355:2085-98. [PMID: 17108343] Google Scholar4 Drüeke TB, Locatelli F, Clyne N, et al. Normalization of hemoglobin level in patients with chronic kidney disease and anemia. N Engl J Med. 2006;355:2071-84. [PMID: 17108342] Google Scholar Author, Article, and Disclosure InformationAffiliations: Brigham and Women’s Hospital, Boston, Massachusetts, USA (T.V.P.)This article was published at Annals.org on 2 March 2010. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 16 March 2010Volume 152, Issue 6Page: JC3-9KeywordsAnemiaChronic kidney diseaseFatigueHeart failureMedical dialysisMyocardial infarctionRenal failureStrokeType 2 diabetes ePublished: 16 March 2010 Issue Published: 16 March 2010 CopyrightCopyright © 2010 by American College of Physicians. All Rights Reserved.PDF DownloadLoading ...