二甲双胍
安普克
医学
作用机理
药品
糖尿病
机制(生物学)
药理学
2型糖尿病
生物信息学
内分泌学
动作(物理)
生物
蛋白激酶A
激酶
细胞生物学
生物化学
哲学
体外
物理
认识论
量子力学
作者
Marc Foretz,Bruno Guigas,Luc Bertrand,Michael Pollak,Benoı̂t Viollet
标识
DOI:10.1016/j.cmet.2014.09.018
摘要
Metformin is currently the first-line drug treatment for type 2 diabetes. Besides its glucose-lowering effect, there is interest in actions of the drug of potential relevance to cardiovascular diseases and cancer. However, the underlying mechanisms of action remain elusive. Convincing data place energy metabolism at the center of metformin's mechanism of action in diabetes and may also be of importance in cardiovascular diseases and cancer. Metformin-induced activation of the energy-sensor AMPK is well documented, but may not account for all actions of the drug. Here, we summarize current knowledge about the different AMPK-dependent and AMPK-independent mechanisms underlying metformin action.
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