Structural modifications associated with the change in Ca2+ sensitivity on activation of m‐calpain

Autolysis of the Ca 2+ ‐dependent cysteine protease m‐calpain involves cleavage of the large (80 kDa) and small (30 kDa) subunits of the enzyme, and an increase in Ca 2+ sensitivity. The appearance of increased Ca 2+ sensitivity was found to correlate with the cleavage of the large subunit after residue 9.