胶质纤维酸性蛋白
内斯汀
生物
星形胶质细胞
中间灯丝
GFAP染色
中间丝蛋白
中枢神经系统
波形蛋白
细胞生物学
神经科学
平衡
神经胶质
下调和上调
神经丝
细胞骨架
免疫学
神经干细胞
干细胞
细胞
免疫组织化学
遗传学
基因
作者
Elly M. Hol,Milos Pekny
标识
DOI:10.1016/j.ceb.2015.02.004
摘要
Glial fibrillary acidic protein (GFAP) is the hallmark intermediate filament (IF; also known as nanofilament) protein in astrocytes, a main type of glial cells in the central nervous system (CNS). Astrocytes have a range of control and homeostatic functions in health and disease. Astrocytes assume a reactive phenotype in acute CNS trauma, ischemia, and in neurodegenerative diseases. This coincides with an upregulation and rearrangement of the IFs, which form a highly complex system composed of GFAP (10 isoforms), vimentin, synemin, and nestin. We begin to unravel the function of the IF system of astrocytes and in this review we discuss its role as an important crisis-command center coordinating cell responses in situations connected to cellular stress, which is a central component of many neurological diseases.
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