Adsorbents in blood purification: From lab search to clinical therapy

Various types of porous resins adsorbents based on polystyrene, polyvinyl alcohol, cellulose as matrixes and DNA, amino acids with other biological active molecules as ligands were extensively studied at Nankai University. Molecular recognition between the ligand and pathogenic molecule was investigated. Several commercialized products are now widely used in hospitals all over China. Whole blood hemoperfusion are used to treat patients suffering from autoimmune diseases, uremia acute intoxication and hyperbilirubinemia. Clinical performances of hundreds and thousands of patients, treated by whole blood sorption therapy are safe, efficient (90%) and cost-effective.