辅酶Q10
氧化应激
线粒体
辅酶Q-细胞色素c还原酶
抗氧化剂
线粒体呼吸链
呼吸链
呼吸系统
辅因子
医学
人口
化学
心脏病学
内科学
生理学
内分泌学
生物化学
环境卫生
酶
细胞色素c
作者
Franklin Rosenfeldt,Salvatore Pepe,Anthony W. Linnane,Phillip Nagley,Michael Rowland,Ruchong Ou,Silvana Marasco,William Lyon,Donald S. Esmore
标识
DOI:10.1111/j.1749-6632.2002.tb02106.x
摘要
With aging of the population, increasing numbers of elderly patients are presenting for cardiac surgery. However, the results in the elderly are inferior to those in the young. A likely contributing factor is an age-related reduction in cellular energy production in the myocardium during surgery, which is known to induce aerobic and ischemic stress. The lipophilic antioxidant and mitochondrial respiratory chain redox coupler, coenzyme Q10 (CoQ10), has the potential to improve energy production in mitochondria by bypassing defective components in the respiratory chain as well as by reducing the effects of oxidative stress. We hypothesized that CoQ10 pretreatment prior to stress could improve the recovery of the myocardium after stress.
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