医学
阿司匹林
胶囊内镜
内科学
内窥镜检查
胃肠病学
置信区间
胶囊
前瞻性队列研究
小剂量阿司匹林
风险因素
植物
生物
作者
Hiroki Endo,Eiji Sakai,Leo Taniguchi,Takaomi Kessoku,Yasuhiko Komiya,Akiko Ezuka,Hiroshi Kawamura,Masataka Taguri,Takuma Higurashi,Hidenori Ohkubo,Eiji Yamada,Atsushi Nakajima,Masahiko Inamori,Shin Maeda,Takashi Sakaguchi,Yasuo Hata,Hajime Nagase
标识
DOI:10.1016/j.gie.2014.03.024
摘要
To develop appropriate management strategies for patients who take low-dose aspirin, it is important to identify the risk factors for GI injury. However, few studies have described the risk factors for small-bowel injury in these patients.To investigate factors influencing the risk of small-bowel mucosal breaks in individuals taking continuous low-dose aspirin.Capsule endoscopy data were collected prospectively from 5 institutions.Yokohama City University Hospital and 4 other hospitals.A total of 205 patients receiving treatment with low-dose aspirin for over 3 months.Colonoscopic and upper GI endoscopy had been performed in all of the patients before the capsule endoscope evaluation.Risk factors for small-bowel mucosal breaks.Of the 198 patients (141 male; mean age 71.9 years) included in the final analysis, 114 (57.6%) had at least 1 mucosal break. Multivariate analysis identified protein pump inhibitor (PPI) use (OR 2.04; 95% confidence interval [CI], 1.05-3.97) and use of enteric-coated aspirin (OR 4.05; 95% CI, 1.49-11.0) as independent risk factors for the presence of mucosal breaks.Cross-sectional study.PPI use appears to increase the risk of small-bowel injury in patients who take continuous low-dose aspirin. Clinicians should be aware of this effect of PPIs; new strategies are needed to treat aspirin-induced gastroenteropathy.
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