胆汁酸
肝再生
核受体
细胞生物学
G蛋白偶联胆汁酸受体
平衡
生物
信号转导
化学
焊剂(冶金)
内科学
法尼甾体X受体
内分泌学
再生(生物学)
受体
生物化学
基因
医学
转录因子
有机化学
作者
Wendong Huang,Ke Ma,Jun Zhang,Mohammed Qatanani,James Cuvillier,Jun Li,Bingning Dong,Xiongfei Huang,David D. Moore
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2006-04-14
卷期号:312 (5771): 233-236
被引量:579
标识
DOI:10.1126/science.1121435
摘要
Liver mass depends on one or more unidentified humoral signals that drive regeneration when liver functional capacity is diminished. Bile acids are important liver products, and their levels are tightly regulated. Here, we identify a role for nuclear receptor-dependent bile acid signaling in normal liver regeneration. Elevated bile acid levels accelerate regeneration, and decreased levels inhibit liver regrowth, as does the absence of the primary nuclear bile acid receptor FXR. We propose that FXR activation by increased bile acid flux is a signal of decreased functional capacity of the liver. FXR, and possibly other nuclear receptors, may promote homeostasis not only by regulating expression of appropriate metabolic target genes but also by driving homeotrophic liver growth.
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