Objective To observe the effect of different kinds of flaps on the healing of wounds with soft tissue defect and infection. Since March, 1995, 57 patients were treated with flaps for the closure of limb wounds with soft tissue defect, topical infection and deep tissue exposure of bones, tendons and nerves. Among these flaps 32 were free flaps, 7 facial flaps and 18 island flaps. 54 cases gained one stage wound healing, 2 cases had suppurative secretion postoperatively and finally gained delayed healing after changing of paid dressing, 1 case with free flap transfer had partial flap necrosis and finally gained healing after skin grafting. Through 2 ~ 4 years follow-up study we conclude that flap transfer could functionally and morphologically repair wounds with soft tissue defect and infection.