Protective Effect of Esterified Phenolic Compounds from Gastrodia elata Blume. on Cerebral Ischemia-reperfusion Injury

The main aim was to investigate the protective effect of esterified phenolic compounds from Gastrodia elata Blume.on cerebral ischemia-reperfusion injury.The middle cerebral artery occlusion(MCAO) model was used.The neurological score,infarct volume,brain tissue water content,and brain tissue Calmodulin-dependent proteinkinase Ⅱ(CaMKⅡ) expression were evaluated.The results showed that esterified phenolic compounds of G.elata could significantly improve the neurological symptoms,reduce infarct volume and cerebral edema,regulate the expression of CaMKⅡ.Esterified phenolic compounds of G.elata had a significant protective effect on cerebral ischemia-reperfusion injury.