Research on total flavonoids bioactivity of edible fungus

In this study, four kinds of total flavonoids were extracted from Pleurotus citrinopileatus, Pleurotus geesteranus, Auricularia auricula and Pleurotus ostreatus, and determined the content in fruiting bodies. We compared the bioactivities among 4 kinds of flavonoids that antioxidative activities of flavonoids were detected by DPPH and FRAP methods. The antiproliferative activities also were examined against MCF7 cells. It was found that the content of flavonoids in Pleurotus ostreatus was highest, followed by Pleurotus citrinopileatus, Pleurotus geesteranus and Auricularia auricula. The ability of free radical scavenging was different among mushroom strains, IC50 values of Pleurotus citrinopileatus, Pleurotus ostreatus, Pleurotus geesteranus and Auricularia auricula were 6.77 μg/mL, 8.58 μg/mL, 11.32 μg/mL and 12.97 μg/mL, respectively. The flavonoids in Pleurotus ostreatus were determined with the highest bioactivities in FRAP assays, and showed the highest antiproliferative activity with IC50 values 4.17 μg/mL. In all, Pleurotus ostreatus was advanced strain in the four kinds of mushroom in this study which should be further research in future.