Ganoderma polysaccharides have a wide range of biological activities,such as immuno-modulating,anti-tumor,antioxidant,hypolipidemic,anti-radiation and hepatoprotective activity,etc. However,the wild fruiting bodies of Ganoderma lucidum is rare,and the production of fruiting bodies and spores includes a long cultivation. It is an importantly alternative method to produce Ganoderma polysacchrides by submerged culture of G. lucidum. The progress of Ganoderma polysacchrides production by submerged culture of G. lucidum was reviewed,and further research outlook was put forward in this paper.