Objective To investigate the correlation between serum resistin and blood lipids in old male patients.Methods A total of 220 male patients over 80 years old were selected and divided into hyperlipidemia group(n=80) and normal lipid group(n=140) according to their blood lipids level.The serum resistin concentration was measured by ELISA.Results Serum resistin level was significantly higher in hyperlipidemia group than in normal lipid group[(7.16±0.77) ng/ml vs.(6.21±0.63) ng/ml,P0.05].Serum resistin level was negatively correlated with TC,LDL-C,HDL-C(γ=-0.231,-0.254,-0.243,all P0.01),and positively correlated with TG(γ=0.127,P0.01).Resistin was independently correlated with HDL-C after controlling the age and medical history(P=0.017).Conclusions Serum resistin level is higher in old male patients with hyperlipidemia and may be related to the disorder of blood lipid.