Preparation of a Cyclomaltoheptaose(β-cyclodextrin) cross-linked Chitosan Derivative via Glyoxal or Glutaraldehyde

A cyclomaltoheptaose-β-Cyclodextrin(β-CD) crosslinked chitosan derivative via glyoxal or glutaraldehyde was prepared.The structures of β-CD crosslined chitosan with glyoxal(Ⅰ) or glutaraldehyde(Ⅱ) were characterized by IR spectra.The surface morphology of the β-CD crosslinked chitosan particles was examined using a scanning electron microscope.Chitosan-linked cyclodextrin beads have highly porous structure.The immobilization capacity of β-CD on chitosan was affected on the weight ratio of β-CD/chitosan,the utilization amount of crosslinking agent,the acidity of the reaction system and the temperature.The results showed that the maximum amounts of β-CD was immobilized into chitosan by glyoxal under the optimum conditions: temperature 80℃,weight ratio(β-CD/chitosan)6∶1,molar ratio(glyoxal/β-CD) 4∶1,and by glutaraldehyde: temperature 85℃,weight ratio(β-CD/chitosan) 6∶1,molar ratio(glutaraldehyde/β-CD)3∶1.The β-Cyclodextrin(β-CD) crosslinked chitosan derivative as adsorbent has high adsorption capacity for unconjugated bilirubin.