Establishment of congenic strains of hairless mice

Aim:To breed the new congenic strains of hairless mice, and study the expression of hairless gene in different hereditary backgrounds. Methods:Hairless gene was transferred into 615,C 57 BL/6,BALB/c, and DBA/2 inbred strains by cross intercross, respectively. Results:The 4th generation breeding had been accomplished. The mice of all 1st and 3rd hybrid generations all had hair and the 4 kinds of 615,C 57 BL/6,BALB/c, DBA/2 hairless mice had been bred successfully by intercrossing in the 2nd and 4th generations, whose regularity of hair losing was the same as YuYi hairless mice. Conclusion:The hairless gene can be expressed in different hereditary backgrounds.