聚乙二醇
光热治疗
光致聚合物
聚合
透皮
活力测定
自愈水凝胶
材料科学
光热效应
PEG比率
紫外线
自由基聚合
化学工程
纳米技术
化学
高分子化学
细胞
有机化学
聚合物
光电子学
生物化学
工程类
复合材料
经济
药理学
医学
财务
作者
Hwang-Jae Lee,Solchan Chung,Min-Gon Kim,Luke P. Lee,Jae Young Lee
标识
DOI:10.1002/adhm.201600048
摘要
Photopolymerization of hydrogels has been widely used to encapsulate cells and support their growth in 3D environments. However, common light sources (i.e., ultraviolet and visible light) strongly interact with biological systems and are therefore inappropriate for in vivo applications, such as transdermal polymerization. Using near infrared (NIR) light that minimally interacts with living tissues, this study investigates NIR light-assisted photothermal polymerization (NAPP) of diacrylated polyethylene glycol (PEGDA), in which interactions between NIR light and gold nanorods activate a thermal initiator (i.e., AIPH), resulting in generation of radicals for polymerization of PEGDA. Gelation parameters, including precursor concentrations and NIR power, are investigated to minimize the use of initiator and temperature increases (<43 °C) during NAPP. Cell viability is as high as 80% after NAPP-based encapsulation. Incorporation of polyethylene glycol (PEG) modified with a cell-adhesive peptide moiety (Arg-Gly-Asp) into the gel system further enables prolongation of cell viability during incubation up to 7 d. NAPP results in successful transdermal gelation and good viability of the transplanted cells. Thus, this new cell encapsulation approach, demonstrated for the first time in this study, will benefit various applications, including cell delivery and remote control over cellular environments.
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