Two Chroman Type Polyketides From Trichoderma sp. YUD24002 Associated With Aconitum

ABSTRACT Two previously undescribed chroman‐type polyketides, trichrontides A ( 1 ) and B ( 2 ), along with four known homologous compounds, were isolated from the endophytic fungus Trichoderma sp. YUD24002, which was associated with Aconitum forrestii Stapf. Their structures were confirmed using NMR and HR‐ESI‐MS techniques. Furthermore, the absolute configurations of the two new compounds were elucidated through TDDFT ECD calculations and Mosher's methods. Notably, compound 1 exhibited significant antifungal activity against Alternaria panax , with a minimum inhibitory concentration (MIC) of 16 µ g/mL, while compound 2 demonstrated evident antifungal activity against Epicoccum nigrum , with a MIC of 32 µ g/mL.