Size optimization of mesoporous β-Cyclodextrin Metal-Organic frameworks as Bio-MOFs

In this study synthesis and size optimization of the β-cyclodextrin-metal–organic framework (β-CD-MOF) with potassium as the metal node through the vapor diffusion method was carried out. The effect of different solvents (methanol, ethanol, acetone, and acetonitrile), temperature (40, 50, and 60 °C), time (6, 12, and 24 h), the molar ratio of β-CD to KOH (1:4, 1:8 and 1:16) and different amount of CTAB (0, 56 and 112 mg) was investigated. One factor at a time approach was implemented and the optimum condition obtained from each parameter was used to synthesize a final crystal structure. Increasing time, temperature, and CTAB concentration reduced the size of the crystals. Methanol produced uniform morphology and smaller crystal size, and the optimum molar ratio of β-CD to KOH was obtained to be 1:8. The optimized particle had an average size of 301 ± 13 nm and surface area of 1123 m2/g, with mean pore diameter 2.2 nm.