乙炔
废止
化学
催化作用
氧化还原
异喹啉
反应机理
基质(水族馆)
戒指(化学)
药物化学
醋酸乙烯酯
光化学
组合化学
有机化学
共聚物
地质学
聚合物
海洋学
作者
T. K. Rana,Arijit Ghosh,Yogesh N. Aher,Amit B. Pawar
出处
期刊:ACS omega
[American Chemical Society]
日期:2023-07-05
卷期号:8 (28): 25262-25271
被引量:3
标识
DOI:10.1021/acsomega.3c02352
摘要
We have developed Cp*Co(III)-catalyzed redox-neutral synthesis of 3,4-unsubstituted isoquinoline 1(2H)-ones at ambient temperature using N-chloroamides as a starting material. The reaction utilizes vinyl acetate as an inexpensive and benign acetylene surrogate. The N-Cl bond of the N-chlorobenzamides plays the role of an internal oxidant and hence precludes the need for an external oxidant. The reaction works with a wide range of substrates having various functional groups and a substrate containing a heterocyclic ring. Notably, the reaction is extended to the N-chloroacrylamides in which vinylic C-H activation occurs to furnish the 2-pyridone derivatives. Preliminary mechanistic studies were also conducted to shed light on the mechanism of this reaction.
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