During the Covid 19 pandemic, employees experienced fear of uncertainty. We hypothesise that gratitude and mindfulness practices would help reduce the intolerance of uncertainty (IU) and increase employee well-being. Data were collected from 283 working professionals. The partial least square structural equation modelling (PLS-SEM) was used to analyse the data. The findings suggest that IU has a negative impact on well-being and there is a mediating effect of gratitude and mindfulness practices between IU and well-being. This study is unique in terms of understanding the role of gratitude and mindfulness in reducing the negative impact of IU on well-being.