树枝状尖峰
索马
神经生物学中的符合检测
神经科学
帕尔瓦布明
物理
海马结构
AMPA受体
生物
枝晶(数学)
NMDA受体
解剖
兴奋性突触后电位
抑制性突触后电位
巧合
医学
病理
生物化学
受体
替代医学
数学
几何学
作者
Linda Judák,Balázs Chiovini,Gábor Juhász,Dénes Pálfi,Zsolt Mezriczky,Zoltán Szadai,Gergely Katona,Benedek Szmola,Katalin Ócsai,Bernadett Martinecz,Anna Mihály,Ádám Dénes,Bálint Kerekes,Áron Szepesi,Gergely Szalay,István Ulbert,Zoltán Mucsi,Botond Roska,Balázs Rózsa
标识
DOI:10.1038/s41467-022-34520-1
摘要
Neuronal plasticity has been shown to be causally linked to coincidence detection through dendritic spikes (dSpikes). We demonstrate the existence of SPW-R-associated, branch-specific, local dSpikes and their computational role in basal dendrites of hippocampal PV+ interneurons in awake animals. To measure the entire dendritic arbor of long thin dendrites during SPW-Rs, we used fast 3D acousto-optical imaging through an eccentric deep-brain adapter and ipsilateral local field potential recording. The regenerative calcium spike started at variable, NMDA-AMPA-dependent, hot spots and propagated in both direction with a high amplitude beyond a critical distance threshold (~150 µm) involving voltage-gated calcium channels. A supralinear dendritic summation emerged during SPW-R doublets when two successive SPW-R events coincide within a short temporal window (~150 ms), e.g., during more complex association tasks, and generated large dSpikes with an about 2.5-3-fold amplitude increase which propagated down to the soma. Our results suggest that these doublet-associated dSpikes can work as a dendritic-level temporal and spatial coincidence detector during SPW-R-related network computation in awake mice.
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