化学
钆
脂质体
磁共振成像
微球
纳米颗粒
戊酸
螯合作用
核磁共振
生物物理学
生物化学
纳米技术
放射科
工程类
物理
生物
有机化学
医学
材料科学
化学工程
作者
Denis A Margalik,Juan Chen,Tiffany Ho,Lili Ding,Alexander Dhaliwal,Andréa S. Doria,Gang Zheng
标识
DOI:10.1021/acs.bioconjchem.2c00445
摘要
Porphysomes (PS) were explored to incorporate different types of diethylenetriaminepentaacetic-acid-gadolinium-(III) (Gd-DTPA)-lipids into their bilayer membrane to assess PS potential as an MRI contrast agent. The Gd-dPS-BSA by integration of over 30% Gd-DTPA-bis(stearylamide) (Gd-DTPA-BSA)-lipids in PS construction resulted in exceptional serum stability and T1 and T2 relaxivity measurements of 13 mM–1 s–1 and 19 mM–1 s–1, respectively. The Gd-dPS-BSA demonstrated significantly enhanced retention in blood circulation with a half-life of 13.6 h and high tumor accumulation up to 19.5%ID/g at 72 h post-injection in select cancer mouse models. Additionally, Gd-dPS-BSA displayed excellent MRI tumor enhancement over 24, 48, and 72 h with contrast enhancements from the baseline of 35.8%, 38.2%, and 38.3%, respectively. Results reported here highlight a high-density incorporation of Gd-DTPA-BSA-lipids within PS, and other liposome formulations can enhance circulatory longevity, independently of particles’ concentration, suggesting effective MRI contrast agent potential for Gd-dPS-BSA and potential utility of Gd-DTPA-BSA-lipids to enhance other liposomal-influenced diagnostic and therapeutic functions.
科研通智能强力驱动
Strongly Powered by AbleSci AI