聚乙二醇干扰素
医学
免疫学
病毒学
慢性肝炎
病毒
利巴韦林
作者
Man‐Fung Yuen,Young‐Suk Lim,Ki Tae Yoon,Tien Huey Lim,Jeong Heo,Pisit Tangkijvanich,Won Young Tak,Vaidehi Jatin Thanawala,Daniel Cloutier,Shenghua Mao,Andre Arizpe,Andrea L. Cathcart,Sneha V. Gupta,Carey K. Hwang,Edward John Gane
标识
DOI：10.1016/s2468-1253(24)00237-1
摘要
Chronic hepatitis B virus (HBV) remains a global concern, with current treatments achieving low rates of HBsAg seroclearance. VIR-2218 (elebsiran), a small interfering RNA agent against HBV transcripts, reduces HBsAg concentrations. We aimed to evaluate the safety and antiviral activity of VIR-2218 with and without pegylated interferon-alpha-2a treatment in participants with chronic HBV.
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(2025-6-4)
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