Personalized Noninvasive Neuromodulation for Obsessive Compulsive Behaviors

Existing theories in biological psychiatry implicate the orbitofrontal cortex (OFC) within the pathological neural architecture of obsessive-compulsive (OC) tendencies, with reward processing, a fundamental cognitive function subserved by the OFC, considered a candidate cognitive dimension underlying such behaviors. Rhythmic brain activity patterns, particularly in the high beta-low gamma frequency range (20-35 Hz), have been demonstrated to facilitate reward processing in the healthy brain, and their dysfunction is thought to contribute to neuropsychiatric abnormalities.