A Photothermal Therapy Study Based on Electrospinning Nanofibers Blended and Coated with Polydopamine Nanoparticles

Abstract The development of high‐efficiency and good biocompatible photothermal therapy platforms is conducive to avoiding the risks of nano‐preparations in vivo . The poly‐L‐lactic acid (PLLA) indicated good biodegradability and biocompatibility. Inspired by natural melanin and the extraordinary nontoxic mussel biopolymer, polydopamine nanoparticles (PDA NPs) with photothermal efficacy have attracted increasing attention. Herein, we performed the study of blended PDA/PLLA and coated PDA@PLLA electrospun nanofibers (ESNFs) for photothermal therapy. In photothermal experiment, the PDA@PLLA ESNF displayed higher light‐to‐heat conversion and photothermal stability than that of PDA/PLLA and PLLA ESNF. Both in vitro and in vivo experiments tested that three kinds of ESNF exhibited low toxicity and outstanding biocompatibility. Moreover, the PDA@PLLA ESNF showed better property for the cell proliferation due to the rough surface and good hydrophilicity. The in vivo photothermal potentiality of the PLLA, PDA/PLA and PDA@PLLA ESNF was evaluated in nude mice of inoculating the tumor, in which the PDA/PLA and PDA@PLLA ESNF significantly inhibited the tumor increasing compared to control group. Especially, the PDA@PLLA ESNF showed better photothermal therapy, which made the tumor irreversible ablate at local tumor tissue. These results stand out the usage of PDA@PLLA ESNF as potential photothermal therapy material.