抗药性
疾病
药品
白血病
医学
机制(生物学)
急性白血病
癌症
生物信息学
免疫学
癌症研究
生物
药理学
内科学
遗传学
哲学
认识论
作者
Alexander Calderon,Cuijuan Han,Sadik Karma,Eric Wang
标识
DOI:10.1016/j.trecan.2023.09.003
摘要
Acute leukemia is characterized by clonal heterogeneity that contributes to poor drug responses in patients. Despite treatment advances, the occurrence of relapse remains a major barrier to achieving cures as current therapeutic approaches are inadequate to effectively prevent or overcome resistance. Given that only a few genetic mutations are associated with relapse in acute leukemia patients, there is a growing focus on ‘non-genetic’ mechanisms that affect the hallmarks of cancer to allow leukemic cells to survive post therapy. In this review, we provide an overview of the therapeutic landscape in acute leukemias. Importantly, we discuss non-genetic mechanisms exploited by leukemic cells to promote their survival after treatment. Last, we present current strategies to prevent or overcome drug resistance in this disease.
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